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5-Amino-1MQ
How it works
5-Amino-1MQ blocks the NNMT enzyme, which keeps NAD+ and SAM inside the cell, switches on SIRT1, shrinks fat cells and wakes up aged muscle stem cells.
Sources
Read the original sources
- 5-Amino-1MQ: NNMT inhibition in mice (2017 · Published abstract · checked 2026-10-08)
- Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity, Kraus 2014, Nature (Abstract · checked 2026-10-13)
- The methionine cycle and its disruption, 2024, Advances in Molecular Oncology (Russia) (Summary · checked 2026-10-13)
- 5-Amino-1MQ: mouse pharmacology (2024 · Published abstract · checked 2026-10-08)
- NNMT inhibitor activates senescent muscle stem cells and improves regeneration of aged muscle, Neelakantan 2019, Biochem Pharmacol (Abstract · checked 2026-10-13)