Cycles and breaks

The cycle is set by biology: the nerve rebuilds its machinery over three to four months and the muscle comes back whether you plan for it or not. Going longer between sessions is fine and simply means living with the return. Going much shorter is what drives the body to build antibodies against the protein, which is the one way this stops working for a person, so the interval of around twelve weeks exists for a reason. A break of a year changes nothing about whether it will work again.