‹ Back
BPC-157
The story
The story starts in Zagreb, Croatia, in the early 1990s. Predrag Sikiric and Sven Seiwerth at the University of Zagreb asked how the stomach survives acid, stress and injury every day. In 1993 they described a protective peptide in gastric juice and named the 15 amino acid piece BPC-157. Over thirty years, the Zagreb group published hundreds of papers on its effects in gut, liver, bone, tendon, muscle, nerve and vessel. Taiwanese teams at Chang Gung University then mapped how it works inside tendon and vessel cells, and Polish reviewers in Warsaw and Gdansk gathered the whole body of work and its patents in 2025.
Sources
Read the original sources
- A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. (Sikirić · 1993 · Abstract; full methods not assumed · checked 2026-10-13)
- BPC-157 in experimental liver injury, Zagreb 1993 (Abstract; original injury model · checked 2026-10-13)
- Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract (Abstract · checked 2026-10-13)
- The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration (Abstract · checked 2026-10-13)
- BPC-157: VEGFR2 signalling and animal models (Hsieh and colleagues · 2017 · Published abstract · checked 2026-10-08)
- Multifunctionality and Possible Medical Application of the BPC 157 Peptide: Literature and Patent Review (Warsaw and Gdansk, Poland, 2025) (Full text · checked 2026-10-13)
- Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: angiogenesis and the NO-system (Sikiric, Zagreb, 2025) (Summary · checked 2026-10-13)