‹ Back
Cagrilintide and Semaglutide Blend
How it is taken
The schedule
| Route | Injection under the skin |
|---|---|
| Amount to start | 0.5 mg |
| How often | Once a week |
| When | Same day each week, any time of day |
| Steps up and down |
|
| How long | 6 to 16 months |
| Cycle | One continuous course, then a lower maintenance dose |
| Mixing | Add 2 mL bacteriostatic water slowly down the side of the vial. Swirl, never shake. |
| Storage | Before mixing: cool and dark. After mixing: fridge at 2 to 8 C, use within 28 days, never freeze. |
CagriSema is injected under the skin once a week, on the same day each week. With the usual 1 to 1 blend, it starts at 0.5 mg of blend a week (0.25 mg of each) for 4 weeks, then steps up every 4 weeks to 1 mg, 2 mg, 3.4 mg and finally 4.8 mg of blend (2.4 mg of each). It runs as one continuous course of 6 to 16 months.
Dose calculator
Change any box to work out a different amount.
How it works: strength per mL = vial strength ÷ water added. mL to draw = dose ÷ strength per mL. Units on a U-100 insulin syringe = mL × 100 (1 mL = 100 units). Doses per vial = vial strength ÷ dose. 1 mg = 1000 mcg.
Your personal schedule is set after we review your survey.
Sources
Read the original sources
- REDEFINE-1: cagrilintide with semaglutide (Garvey and colleagues · 2025 · Published abstract · checked 2026-10-08)
- Cagrilintide protocol, Peptide Dosing Protocols (Full text · checked 2026-10-13)