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Cagrilintide
How it works
Cagrilintide replaces the amylin fullness signal: it acts on the brainstem gate that ends a meal, on amylin and calcitonin receptors that restore leptin sensitivity, and on the stomach and glucagon to flatten the sugar curve.
Sources
Read the original sources
- Amylinergic control of food intake in lean and obese rodents, Boyle 2011, Physiology and Behavior (Abstract · checked 2026-10-13)
- Development of cagrilintide, a long-acting amylin analogue, Kruse 2021, J Med Chem (Abstract · checked 2026-10-13)
- New pancreatic hormones: amylin, a literature review, 2014, Universum: Medicine and Pharmacology (Russia) (Summary · checked 2026-10-13)
- AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists. (Fletcher · 2021 · Abstract; full methods not assumed · checked 2026-10-13)
- Pharmacology of the calcitonin and CGRP family of peptides, IUPHAR Review 25, Hay 2018, Br J Pharmacol (Abstract · checked 2026-10-13)
- Effect of amylin on beta-cell function and carbohydrate metabolism, 2008, Diabetes Mellitus (Russia) (Summary · checked 2026-10-13)
- Purification and characterization of amylin from pancreases of people with type 2 diabetes, Cooper 1987, PNAS (Abstract · checked 2026-10-13)