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CJC-1295, without DAC · How it works
Built to survive DPP-4
The enzyme DPP-4 cuts natural GHRH between amino acids 2 and 3 and kills it in minutes. D-alanine at position 2 blocks that cut. The other three swaps stop the peptide from rearranging and oxidising. It stays active long enough to give a full pulse, then clears.
Sources
Read the original sources
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. (Jetté · 2005 · Abstract; full methods not assumed · checked 2026-10-13)