Above GnRH, not beside it

Kisspeptin binds KISS1R, also called GPR54, a G-protein coupled receptor sitting on the GnRH neurons of the hypothalamus. Binding runs through Gq, phospholipase C, IP3 and DAG, which depolarises the neuron and makes it fire. The GnRH it releases travels the short portal vessels to the pituitary, which answers with LH and FSH, and those reach the testis or ovary to make testosterone or oestrogen. Kisspeptin therefore sits one level above the entire chain, which is why it moves the whole axis rather than one hormone.