The schedule

The shape that works is on and off, every day. In the human work that was eight hours of exposure followed by sixteen hours clear, repeated daily, which held LH raised for the full twelve days it was run. Single doses into a vein raise LH within thirty minutes and fade within hours, which suits a diagnostic question rather than a course. For egg maturation it is one dose, timed about 36 hours ahead of collection. Every one of those schedules is set and run by the clinicians measuring the response.