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MOTS-c
How it works
MOTS-c switches on AMPK, pulls glucose into muscle, moves into the nucleus under stress and keeps ageing muscle working like younger muscle.
Sources
Read the original sources
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. (2015 · Abstract; full methods not assumed · checked 2026-10-13)
- The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress (Abstract · checked 2026-10-13)
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Full text · checked 2026-10-13)
- Exercise and endogenous MOTS-c in people (2021 · Published abstract · checked 2026-10-08)