Going up and down

Nausea is the ceiling and it is the reason this molecule is started low and raised slowly by whoever is supervising. At the amount used in the Arizona work, severe nausea hit about one person in eight, and that was with clinicians present. Weight matters, since the dosing there was calculated per kilogram. The sensible direction is always down first: the pigment effect accumulates even at amounts well below the ones that cause sickness.