Melanotan II, MT-2
In people
The arousal effect is the fastest and least subtle. In the Arizona work erections appeared with no sexual stimulation present, within roughly fifteen minutes to four hours of dosing, lasting an average of 38 minutes of firm rigidity against 3 minutes on placebo, and most men reported increased desire with it. Nausea, yawning, stretching and flushing arrive in the same window and come from the same central receptors; nausea was the limiting problem, severe in about one in eight at the higher amount used. Appetite falls noticeably. Colour comes in over one to three weeks and is even rather than patchy, because it is your own eumelanin. The parts people report from unregulated use are the ones worth taking seriously: existing moles going darker, new irregular moles appearing, a handful of melanomas reported in or near moles, prolonged painful erection, and in one documented case muscle breakdown severe enough to cause systemic illness. Analysis of powders sold online has also found that the contents did not reliably match what was claimed, so some of what gets reported belongs to the vial rather than the molecule.
Sources
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- Melanotan II: psychogenic erectile dysfunction (1998 · Published abstract · checked 2026-10-08)
- Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II (Summary · checked 2026-10-13)
- Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review (Abstract · checked 2026-10-13)
- Melanotan II user experience: a qualitative study of online discussion forums (Abstract · checked 2026-10-13)