What you will notice

First hours: flushing, yawning, stretching, a drop in appetite, often some nausea, and in men the arousal effect, which can start within fifteen minutes and run to several hours. First week or two: appetite stays lower, nausea usually settles as the body gets used to the molecule, and the first faint colour appears. Weeks two to four: pigment is clearly in, evenly across face, arms and shoulders, and moles should be compared against the photographs taken at the start. Weeks four to eight: colour plateaus and the arousal and appetite effects persist only while dosing continues. Longer: colour fades over one to two months once dosing stops as pigmented skin cells are shed, and nothing about the receptor is used up. Any mole that darkens, grows, changes shape or starts to itch, and any erection that will not subside, is a reason to stop and be seen the same day.