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PT-141, Bremelanotide · How it works
Arousal through nerves
Signals from the hypothalamus run down the spinal cord to the nerves of the pelvis. In men this produces erections on its own, even when blood-flow drugs have not worked. In women it raises genital arousal and sensation. It works with the body's arousal wiring from the top.
Sources
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- Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra (Summary · checked 2026-10-13)
- Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II (Summary · checked 2026-10-13)