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Retatrutide · What it helps
Energy use and lean tissue
Glucagon raises resting energy expenditure, so the body burns more fuel even when still. That helps offset the normal slowing of metabolism during weight loss. With strong protein intake and resistance training, the share of lean tissue is well protected. The goal is fat off and muscle kept.
Sources
Read the original sources
- LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. (Coskun · 2022 · Abstract; full methods not assumed · checked 2026-10-13)
- Shared mechanistic pathways of glucagon signalling in obesity and fatty liver, Neff 2025, Diabetes Obes Metab (Abstract · checked 2026-10-13)