Tesamorelin · How it works

Brain and the GABA system

GHRH and IGF-1 act on the brain as well as the body. In older adults, daily tesamorelin raised brain GABA, the calming signal, and lowered a harmful lipid in the brain. Executive function, the planning and switching part of thinking, improved. It reaches the brain through IGF-1 and its own GHRH receptors there.

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Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults (Abstract · checked 2026-10-13)