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Tesamorelin
The story
Tesamorelin was developed by Theratechnologies in Montreal, Canada, in the 1990s and 2000s, coded TH9507. Julian Falutz and colleagues in Montreal showed in 2007 that 2 mg a day shrank visceral fat by about 15 percent in 26 weeks while leaving fat under the skin alone. It became the medicine Egrifta in 2010. Later work by Takara Stanley and Steven Grinspoon in Boston showed it also cuts liver fat, and Laura Baker's group in Seattle found it sharpened thinking in older adults.
Sources
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- Metabolic effects of a growth hormone-releasing factor in patients with HIV (Abstract · checked 2026-10-13)
- Tesamorelin: two pooled HIV abdominal-fat trials (2010 · Published abstract · checked 2026-10-08)
- Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation (Abstract · checked 2026-10-13)
- Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults (Abstract · checked 2026-10-13)